In vivo magnetic resonance spectroscopy

In the early 1980s, shortly after the introduction of magnetic resonance imaging (MRI) of the human body in vivo, the first localized in vivo magnetic resonance spectra (MRS) were also acquired. In vivo MRS has evolved during the last 35 years in terms of localization quality and spatial resolution, acquisition speed, artifact suppression, the number of detectable metabolites and the precision of metabolite concentration quantification. The technique has profited especially from improvements in B0 shim quality and the significant increase of magnetic field strength that recently became available for in vivo investigations. Today, in vivo MRS enables non-invasive and non-ionizing determination of metabolite concentrations in tissue and of metabolite chemical kinetic rates. In vivo MRS is applied humans and in animals. It has proven its worth as an important tool for physiological research, in clinical research, and is emerging as a potential clinical diagnostic tool.

The workshop

In addition to late breaking results, this workshop examines the substantial advances in MRS acquisition, processing and analysis methods that have been achieved by the MRS community during the last 10 – 15 years. The workshop will feature invited scientific presentations, proffered papers, a poster session and discussion to work toward consensus in the areas of standardization, harmonization, quality assurance and guidance on best practices in MRS methodology. Besides this, the workshop will offer several optional “hands-on” sessions at the 7T MR scanner in the UMCU and demonstration of new software packages available for MRS.

Target Audience

This workshop is designed for MR Physicists including Ph.D. students; Postdoctoral Fellows and faculty who develop methodology and support clinical and physiological research based on MRS; as well as Psychiatrists, Neurologists, Neuro Radiologists, and Body Radiologists, who will benefit from the comprehensive overview and consensus discussions in order to define the state-of-the art of spectroscopy. The workshop is organized by the MR Spectroscopy Study Group.

Educational Objectives

Upon completion of this activity, participants should be able to:

Describe current MRS(I) data acquisition methodology including sequences, pre-scans and hardware requirements;
Discuss current MRS(I) data processing, reconstruction and analysis methods;
Compare the pro´s and cons´s of advanced MRS and MRSI methods;
Identify advanced MRS(I) methods that made it into application in clinical and basic research;
Summarize minimum quality standards with regard to data acquisition, processing, analysis and reporting for physiological or clinical MRS studies; and
Support the ongoing consensus discussion about state-of-the-art, unmet needs and still existing limitations.